ORF Genetics Ltd. is a global leader in the manufacturing of plant-made recombinant proteins. The company produces and markets recombinant growth factors and cytokines for stem cell research, regenerative medicine and other medical research, biopharmaceuticals and for skin care. It was the first company in the world to market a consumer product based on green biotechnology. The company also offers economical, large scale contract manufacturing of recombinant proteins.

ORF Genetics’ production takes place in a proprietary, biorisk-free production system in barley, bypassing conventional bacteria and animal cell systems.

Environmental responsibility is at the heart of ORF Genetics’ operations. Renewable geothermal energy powers the cultivation of barley in the company’s Green Factory, a high-tech greenhouse in Iceland. Using the company’s proprietary HEKLAgro™ technology, the cultivation takes place in inert volcanic pumice and a fully automatic, patent pending, hydroponic system allows for the production of up to 90 different proteins at a time, with minimum CO2 footprint.


Kristinn Gretarsson 

  • Endotoxin-free Growth Factor – a Paradigm Shift

ORF Genetics offers stem cell researchers high-grade, animal-free and endotoxin-free growth factors under the ISOkine™ brand.

Most growth factors used in stem cell research today are manufactured in E. coli bacteria. The current limit of endotoxin levels in E. coli produced growth factors is 1 EU/µg.  Recent research has however indicated that those levels may be far too high for stem cell cultures, as endotoxins can have profound effect on cell survival and differentiation of stem cells in culture, even at very low concentration. The levels of endotoxins in ISOkine™ growth factors is guaranteed to be at least 20 times lower than in growth factors made in E. coli. ISOkine™ growth factors are therefore the perfect choice for researchers aiming for consistent and reliable performance of their stem cell cultures.

  • Award-winning Skin Care Products

  BIOEFFECT® is an Icelandic skin care brand, based on 10 years of biotechnology research by ORF Genetics.

Representing the future of scientific skin care, the BIOEFFECT skin care products renew the youthful glow and radiance of ageing skin. They contain growth factors which signal the skin to speed up its renewal process and activity. The growth factors are replicas of growth factors found in human skin, produced in barley seeds to ensure maximum efficacy and purity.

The BIOEFFECT skin care range has since its launch in 2010 taken the European anti-ageing skin care market by storm and is currently available in 27 markets, including China, and sold in over 1000 stores.


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